Involvement of lysophosphatidic acid (LPA) in tPA–induced central post stroke pain (CPSP) in mice
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چکیده
منابع مشابه
Lysophosphatidic acid (LPA) signaling in vertebrate reproduction.
Lysophosphatidic acid (LPA) is a cell membrane phospholipid metabolite that can act as an extracellular signal. Its effects are mediated through at least five G protein-coupled receptors, LPA(1-5), and probably others as well. Studies in multiple species including LPAR-deficient mice and humans have identified or implicated important roles for receptor-mediated LPA signaling in multiple aspects...
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Lysophosphatidic acid (LPA), the simplest of the water-soluble phospholipids, can evoke various biological responses. The present study examined the activity of LPA to induce plasma exudation and histamine release in mice. Plasma exudation was assessed by extravasation of Evans blue. Subcutaneous administration of LPA (1 - 100 microg/site) led to increased plasma exudation in the skin. The LPA-...
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15 صفحه اولThe Efficacy of Gabapentin in Patients with Central Post-stroke Pain
Thalamic pain syndrome, a type of central post-stroke pain (CPSP), may develops after a hemorrhagic or ischemic stroke and results in impairment of the thalamus. There is limited experience about gabapentin in treatment of central pains like CPSP.In a prospective observational study, the intensity of pain was recorded using the Numeric Rating Scale (NRS) at the entrance to the study. Patients e...
متن کاملLysophosphatidic acid (LPA) and its receptors.
Lysophosphatidic acid (LPA), a bioactive phospholipid, and its family of cognate G protein-coupled receptors have demonstrated roles in many biological functions in the nervous system. To date, five LPA receptors have been identified, and additional receptors may exist. Most of these receptors have been genetically deleted in mice toward identifying biological and medically relevant roles. In a...
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ژورنال
عنوان ژورنال: PAIN RESEARCH
سال: 2018
ISSN: 0915-8588,2187-4697
DOI: 10.11154/pain.33.269